An older study found that milk thistle extract had a positive effect on immune response in humans. It's typically recommended to avoid taking multiple supplements for the same cause at the same time. In this way, milk thistle may help improve cognition and treat degenerative conditions that affect the mind. Milk thistle is an herbal remedy with rich plant compounds. Soy Protein Vs. Whey Protein: Pros And Con Soy Protein Vs. Whey Protein: Pros And Cons + Which Is Better. Milk thistle is native to Europe and was introduced into North America by early colonists. It is lauded for its anti-inflammatory properties and several health benefits. We avoid using tertiary references. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. Therefore, it is important to talk to your healthcare provider about any supplements you plan to take and to check in about any potential interactions with other supplements or medications. How long does it take for milk thistle to start working? If any of these effects last or get worse, tell your doctor or pharmacist promptly. Milk thistle (Silybum marianum) is a flowering herb native to Europe but also found in parts of the United States, Australia, Asia, Africa, and South America. If you buy through links on this page, we may earn a small commission Heres our process. Milk thistle is also available as a tea. Refer to storage information printed on the package. Milk thistle is generally thought to be safe, but you still may experience side effects when taking it. Before using this product, tell your doctor or pharmacist of all the products you use. Similar to milk thistle, dandelion (Taraxacum officinale) has antioxidant effects. There are 4 drugs known to interact with Several studies have suggested that milk thistle has immunomodulatory effects. 2007;2007(4):CD003620. Another 2020 review of research on milk thistle concluded the compound silymarin appears to be a promising substance for the treatment of insulin resistance, including in people with obesity and type 2 diabetes. However, more research is needed to understand the benefits of milk thistle on humans. [1] Silymarin is a standardized preparation extracted from the fruits (seeds) of milk thistle. Does milk thistle cause any side effects? Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes: Reviewed By: Steven D. Ehrlich, N.M.D., private practice specializing in complementary and alternative medicine, Phoenix, AZ. A 2015 study in worms found that milk thistle increased resistance to oxidative stress. In a 2016 study, researchers fed rats a high-cholesterol diet. Toxicity is also possible if too much milk thistle is taken. Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes: Allergy drugs -- such as fexofenadine (Allegra) Drugs for high cholesterol -- such as lovastatin (Mevacor, Altocor) Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. Although some studies have shown positive results on milk thistle for people with chronic hepatitis C virus (HCV) infection, the overall research does not show a benefit. Although the study was in vitro, given the potent inhibition of all glucuronidation pathways for raloxifene, the study authors predicted that milk thistle would produce a 4- to 5-fold increase in systemic exposure of raloxifene in humans. Others may find them inefficient, while some people swear by them. Researchers think it may also slow down the growth of cancer cells. Milk thistle seeds contain silymarin. Also known by its scientific name, Silybum marianum, milk thistle grows mostly in California, although it can be grown in many other warm climates as well. Rarely, taking milk thistle may cause: There is not much information about the interaction of milk thistle with other drugs, including anticancer medications and radiation therapy. Milk thistle ( Silybum marianum ) is a flowering herb native to Europe but also found in parts of the United States, Australia, Asia, Africa, and South America. Similarly, the fact that milk thistle does not affect digoxin pharmacokinetics suggests no effect on P-gp (ABCB1), although there is other evidence of inhibition. For centuries, this herb has been used in fighting hangovers (9). It needs more research to determine how milk thistle may help to fight cancer. Can diet help improve depression symptoms? Little is known about whether its safe to use milk thistle during pregnancy or while breastfeeding. Phytother Res. Current studies on milk thistle use a wide range of doses. Soleimani V, Delghandi PS, Moallem SA, Karimi G. Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review. The terms "milk thistle" and "silymarin" are often used interchangeably. Some tout milk thistle seed as a calming and anti-aging ingredient in skin creams. Is the ketogenic diet right for autoimmune conditions? Substances in milk thistle may reduce blood sugar. 2014;11(2):167-74. doi:10.1900/RDS.2014.11.167. Review of Clinical Trials Evaluating Safety and Efficacy of Milk Thistle (Silybum marianum [L.] Gaertn. Milk thistle is native to Europe and was introduced into North America by early colonists. Milk thistle is a traditional Chinese medicine extract derived from the mature fruit of Silybum marianum. Scan J Gastroenterol. Herbal remedies are usually the talk of the town. It also looks at how to use milk thistle and whether there are any risks to consider. Keep all medications and herbal products away from children and pets. Front Immunol. Milk thistle ( Silybum marianum L. Some research also states that overall, milk thistle may not pose a great risk for drug interactions in humans (13). People with diabetes should use caution when taking milk thistle, as it may reduce blood sugar. Milk Thistle: Effects on Liver Disease and Cirrhosis and Clinical Adverse Effects: Summary, AHRQ Evidence Report Summeries, National Center for Biotechnology Information, U.S. National Library of Medicine. Does milk thistle interact with my other drugs? Articles on StyleCraze are backed by verified information from peer-reviewed and academic research papers, reputed organizations, research institutions, and medical associations to ensure accuracy and relevance. Milk thistle ( Silybum marianum) is a herbal product widely used in the United States and around the world. Nouri-Vaskeh M, Malek Mahdavi A, Afshan H, Alizadeh L, Zarei M. Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial. As with any natural remedy, people should discuss using milk thistle with a doctor before taking it. Call your doctor for medical advice about side effects. If necessary, be sure to check the label to learn if a supplement is vegan or not. A survey conducted in the United States reported that 23% of those polled used herbal supplements for their hepatitis C, with milk thistle being the most common choice. Weight Loss for Health and Longevity, Science Reveals How Red Meat Harms the Heart, Flavored Vapes Still in Stores Despite Federal Ban, New COVID Antiviral Pills: What You Need to Know, Dr. Whyte's Book: Take Control of Your Cancer Risk, WebMD Loses Cherished Leader Kristy Hammam, Health News and Information, Delivered to Your Inbox. Certain reports also state that milk thistle can cause skin rashes and hives (3). (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Milk thistle comes in many forms, including tea. How should we deal with preliminary information such as this? The common name, milk thistle, is derived from the "milky white" veins on the leaves, which, when broken open, yield a milky sap. There are other supplements that work similarly to milk thistle. Copyright 2011 - 2023 IncNut Stylecraze Private Limited. Milk thistle is thought to be safe for most people, but precautions should be taken as side effects are possible. doi:10.1002/14651858.CD003620.pub3. Duplication is encouraged. milk thistle. But are there any proven health benefits of it? This is not a complete list of side effects and others may occur. A 2012 study found that silymarin helped to protect against inflammation in the airways of mice with allergic asthma. Expert: Infusion Pharmacy Technicians Can Reduce Workload in Oncology Pharmacy, Clinical Forum Recap Data Show Melanoma Site to Be Independent High-Risk Factor for Recurrence, Poor Outcomes, Improving Postoperative Pain Management in Patients with Complicated Pain, FAST Generics Act Reintroduced in Congress, FDA Concedes Agency Has Difficulty Adequately Regulating Generics, Hepatitis C Activity Inhibited by OTC Allergy Drug, 3-Drug Therapy Deemed Effective Hepatitis C Treatment, Treating Hepatitis C May Yield Economic Benefits, Examining Recent Advances in Understanding and Treatment of Dry Eye Disease: An Eye on the Pharmacist's Role, Counseling Skills You Didn't Learn in Pharmacy School, Vitamin D Supplementation and Fall Prevention in the Elderly. 3 are moderate, and 1 is minor. Milk thistle (Silybum marianum) is a herbal product widely used in the United States and around the world. Do not double the dose to catch up. However, the extracts in milk thistle could act like estrogen. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Milk thistle. Continue reading. J Med Assoc Thai. An important part of taking supplements is proper storage. Silybum marianum is a species of thistle.It has various common names including milk thistle, blessed milkthistle, Marian thistle, Mary thistle, Saint Mary's thistle, Mediterranean milk thistle, variegated thistle and Scotch thistle (though not to be confused with Onopordum acanthium or Cirsium vulgare).This species is an annual or biennial plant of the family Asteraceae. Last medically reviewed on December 17, 2021. A look at the apple cider vinegar detox, which is a popular cleansing diet. More studies with human participants could allow scientists to say with certainty that milk thistle supports a persons immune system. If you notice other effects not listed above, contact your doctor or pharmacist. Tajmohammadi A, Razavi BM, Hosseinzadeh H. The survey revealed anecdotal evidence of the improved quality of life among those who took milk thistle, despite having no measurable improvements in hepatitis symptoms like liver inflammation. Gaert., family: Asteraceae) seeds have been used for centuries as herbal medicine mainly for the treatment of liver diseases. gallbladder disorders. If you have any questions about storage, ask your pharmacist. Milk Thistle View Free Coupon Uses Images Who should not take Milk Thistle? It is not yet clear whether milk thistle is equally beneficial for bone loss with a different cause. Yang Z, Zhuang L, Lu Y, Xu Q, Chen X. If drinking milk thistle tea, it is best to limit intake to 6 cups a day. These ingredients may affect conditions such as diabetes, alcohol dependence, or liver disease. 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